Influence of sleep difficulty on post-traumatic stress symptoms among frontline medical staff during COVID-19 pandemic in ChinaArticle Published on 2022-10-012023-07-06 Journal: Psychology, health & medicine [Category] COVID19(2023년), [키워드] COVID-19 mediator medical staff Post-traumatic stress symptoms Sleep. [DOI] 10.1080/13548506.2021.1981411 PMC 바로가기
The Impact of Pandemic-Related Life Stress on Internet Gaming: Social Cynicism and Gaming Motivation as Serial Mediators전염병 관련 생활 스트레스가 인터넷 게임에 미치는 영향: 연쇄적 중재자로서의 사회적 냉소와 게임 동기Article Published on 2022-07-072022-09-12 Journal: International Journal of Environmental Research an [Category] MERS, 진단, [키워드] Analysis association conducted COVID-19 COVID-19 pandemic disorder Effect gaming motivation Hierarchical Hong Kong Impact increasingly influence Internet internet gaming investigated life life stress mechanism mediation model mediator motivation outcome participant positive regressions reported seeking significantly social cynicism. suggested tested turn [DOI] 10.3390/ijerph19148332 PMC 바로가기 [Article Type] Article
Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary Human Lung Microvascular Endothelial Cells In Vitro비만 매개체는 SARS-CoV-2 감염 또는 시험관 내 1차 인간 폐 미세혈관 내피 세포 활성화에 영향을 미치지 않습니다Article Published on 2022-06-282022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] activated Activation addition Adhesion Molecule adipokines adipose Adipose tissue Alter Cell cells clinical clinical observations COVID-19 Critically ill driving dysfunction E-selectin endothelial endothelial activation Endothelial cell endothelial cells Endothelial dysfunction evidenced exacerbate excess exposure to expression fat Human human lung ICAM-1 IL-6 Incubation individuals induce Infection Inflammation Inflammatory Inflammatory cytokine Inflammatory response Inflammatory responses influence initiated lack Leptin leptin. lung Lungs mechanism mediator mounted obese obese COVID-19 patients obesity observation other organs outcome phenotype plasma pro-inflammatory produced virus required response SARS-CoV-2 SARS-CoV-2 entry receptor SARS-COV-2 infection selectin severe disease shown susceptibility susceptibility to infection susceptible systemic level tested tissue VCAM-1 Viral protein Viral proteins virus visceral with COVID-19 [DOI] 10.3389/fimmu.2022.879033 PMC 바로가기 [Article Type] Article
Cytokines and Lipid Mediators of Inflammation in Lungs of SARS-CoV-2 Infected MiceSARS-CoV-2에 감염된 마우스의 폐에서 염증의 사이토카인 및 지질 매개체Article Published on 2022-06-242022-09-11 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료기술, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Alanine Analysis analyzed animal animal model animal models Blood blood clot Blood clots characterized chemokine chemokines circulating clinical manifestation Concentration coronavirus 2 coronavirus disease coronavirus disease 19 correlated COVID-19 Cytokines D-dimer D-dimers different time point different time points elevated ethanolamide event events Features Genes glycerol glycine hallmark highlight histology Human hydroxy indicated Infection Inflammation inflammatory mediator Inflammatory mediators interferons K18-ACE2 knowledge leukocyte leukocyte infiltration Lipid lipid mediator lipid mediators of inflammation lipids lung Lung inflammation lung tissue lung tissues lung viral load Lungs mass spectrometry Measures mediator mice modulation Other Pathogenesis pathogenesis. pathology pathophysiological performed PGF plasma Post-infection produced prostaglandin reduced Replication RNA-seq analysis robust SARS-CoV-2 SARS-COV-2 infection Severe acute respiratory syndrome severe acute respiratory syndrome coronavirus 2 severe COVID-19 significantly Support Tandem mass spectrometry therapeutic strategy transcriptomic transgenic mice treat uninfected vasculature viral replication [DOI] 10.3389/fimmu.2022.893792 PMC 바로가기 [Article Type] Article
Serum Levels of Proinflammatory Lipid Mediators and Specialized Proresolving Molecules Are Increased in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 and Correlate With Markers of the Adaptive Immune Response중증 급성 호흡기 증후군 코로나바이러스 2 환자에서 전염증성 지질 매개체 및 전문 분해 분자의 혈청 수준이 증가하고 적응 면역 반응의 마커와 상관 관계가 있습니다Article Published on 2022-06-152022-09-11 Journal: The Journal of Infectious Diseases [Category] COVID19(2023년), MERS, SARS, 진단, 치료법, [키워드] acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 age Anti-inflammatory Anti-nucleocapsid Anti-spike anti-spike antibody assays binding bioactive lipids Clinical outcome collected Concentration Control coronavirus coronavirus 2 died female hospital identify immune immune response Increased innate response Inpatient Level linoleic acid Lipid lipids male mediator molecule Omega pandemic pathogenic inflammation Pathways Patient patients positive correlation processed proinflammatory quantification Quantitative respiratory response SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 patient SARS-CoV-2 patients serum Serum level serum levels severe acute respiratory syndrome Coronavirus Sex significantly higher significantly lower specialized proresolving molecules. symptomatic SARS-CoV-2 infection transition [DOI] 10.1093/infdis/jiab632 PMC 바로가기 [Article Type] Article
Heparanase Is a Putative Mediator of Endothelial Glycocalyx Damage in COVID-19 – A Proof-of-Concept Study헤파라나제는 COVID-19에서 내피 글리코칼릭스 손상의 추정 매개체입니다 - 개념 증명 연구Article Published on 2022-06-102022-09-12 Journal: Frontiers in Immunology [Category] MERS, 진단, [키워드] atomic Bacterial sepsis changes in Coronavirus disease 2019 correlated COVID-19 COVID-19 patient cultured cell damage dimension disease endothelial endothelial glycocalyx (EG) enzyme excess experiments glycocalyx Heparanase heparanase (HPSE) heparin HPSE immunofluorescence inhibition Injury marker mediator Microscopy plasma plasma sample prevented Protective protective effect serum shown translational Vascular endothelium vessel videomicroscopy. [DOI] 10.3389/fimmu.2022.916512 PMC 바로가기 [Article Type] Article
Combinational benefit of antihistamines and remdesivir for reducing SARS-CoV-2 replication and alleviating inflammation-induced lung injury in miceSARS-CoV-2 복제를 감소시키고 마우스에서 염증 유발 폐 손상을 완화하기 위한 항히스타민제와 렘데시비르의 조합 이점Article Published on 2022-05-182022-09-11 Journal: Zoological research [Category] COVID19(2023년), SARS, 치료제, [키워드] alveolar antagonist Anti-inflammatory Anti-inflammatory therapy Antihistamine Antihistamines Antiviral antiviral drug antiviral therapy benefit caused Chinese clinical benefits Combination Combinational therapy COVID-19 COVID-19 treatment degranulation demonstrated Endothelial cell English epithelial feasible Histamine histamine receptor hyperinflammation Immune-mediated in vivo Inflammation inflammation-induced lung injury inflammatory disease initiate Injury lAbel loratadine Lung injury lung lesion lung lesions mast cell Mast cells MCs mediator mice off-label off-label use predicted Prevent prevented receptor reducing Remdesivir SARS-CoV-2 SARS-COV-2 infection SARS-CoV-2 replication SARS-CoV-2 spike SARS-CoV-2 spike protein SARS-CoV-2. Spike protein suggested suppress Treatment viral replication [DOI] 10.24272/j.issn.2095-8137.2021.469 PMC 바로가기 [Article Type] Article
SARS-CoV-2 electrochemical immunosensor based on the spike-ACE2 complex스파이크-ACE2 복합체 기반 SARS-CoV-2 전기화학 면역센서Article Published on 2022-05-012022-09-11 Journal: Analytica chimica acta [Category] COVID19(2023년), SARS, 치료기술, [키워드] ACE2 acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 angiotensin Angiotensin-converting enzyme anti-spike antibody antibody buffer complex coronavirus coronavirus disease Coronavirus disease 2019 COVID-19 detect Diagnosis enzyme gold healthy individual horseradish peroxidase host receptor HRP immunosensor infected patient infected patients Interaction limit of detection magnetic bead Magnetic beads measure mediator mitigate Nasopharyngeal swab nasopharyngeal swab sample Pandemics Particle Particles peroxidase proof Protein pseudovirions Rapid reporter reproducibility resulting Sandwich SARS-CoV-2 sensitivity severe acute respiratory syndrome Coronavirus spike Spike protein spike protein. the patient the spike protein viral particle Viral particles virus was recorded [DOI] 10.1016/j.aca.2022.339718 PMC 바로가기 [Article Type] Article
Successful Treatment of a Patient With Severe COVID-19 Using an Integrated Approach Addressing Mast Cells and Their MediatorsCase report Published on 2022-05-012022-10-05 Journal: International Journal of Infectious Diseases [Category] COVID19(2023년), SARS, 치료법, [키워드] coronavirus COVID-19 fibrosis flavonoids Inflammation Lungs Mast cells mediator Treatment [DOI] 10.1016/j.ijid.2022.02.049 [Article Type] Case report
Ferulic acid and berberine, via Sirt1 and AMPK, may act as cell cleansing promoters of healthy longevitySirt1과 AMPK를 통한 페룰산과 베르베린은 건강한 장수의 세포 정화 촉진제로 작용할 수 있습니다Review Published on 2022-03-012022-09-11 Journal: Open Heart [Category] SARS, 유전자 메커니즘, 치료기술, [키워드] activating Activation AMPK amplify amplifying anthocyanin Anti-inflammatory effects antioxidant Apoptosis appear autophagy bacterial metabolite benefit berberine biogenesis boost carotid carotid artery carotid artery diseases Cell cell survival cellular cellular senescence Chinese clinically complementary Concentration conjunction coronary angiography deficit detect DNA DNA repair echocardiography echocardiography. Effect endothelial ENhance enzyme expression ferulic acid function functions Health health benefits healthy independent Inflammation inhibiting mechanism mediator mitochondrial molecular basis mRNA NAD+ NF-kB nicotinamide Nrf2 nutraceutical Phase 2 promote promoter Protective protective effect protein level protein levels SARS-CoV-2 spike protein SIRT1 Spike protein survival synergistic the SARS-CoV-2 tissues Toxicity transcription factor turn [DOI] 10.1136/openhrt-2021-001801 PMC 바로가기 [Article Type] Review